Heart Failure Chymase Inhibition Prevents Fibronectin and Myofibrillar Loss and Improves Cardiomyocyte Function and LV Torsion Angle in Dogs With Isolated Mitral Regurgitation
نویسندگان
چکیده
Betty Pat, PhD; Yuanwen Chen, MD, PhD; Cheryl Killingsworth, DVM, PhD; James D. Gladden, BS; Ke Shi, MD; Junying Zheng, PhD; Pamela C. Powell, MS; Greg Walcott, MD, PhD; Mustafa I. Ahmed, MD; Himanshu Gupta, MD; Ravi Desai, MD; Chih-Chang Wei, PhD; Naoki Hase, MS; Tsunefumi Kobayashi, PhD; Abdelkarim Sabri, PhD; Henk Granzier, PhD; Thomas Denney, PhD; Michael Tillson, DVM; A. Ray Dillon, DVM; Ahsan Husain, PhD; Louis J. Dell’Italia, MD
منابع مشابه
Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation.
BACKGROUND The left ventricular (LV) dilatation of isolated mitral regurgitation (MR) is associated with an increase in chymase and a decrease in interstitial collagen and extracellular matrix. In addition to profibrotic effects, chymase has significant antifibrotic actions because it activates matrix metalloproteinases and kallikrein and degrades fibronectin. Thus, we hypothesize that chymase ...
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The low-pressure volume overload of isolated mitral regurgitation (MR) is associated with increased adrenergic drive, left ventricular (LV) dilatation, and loss of interstitial collagen. We tested the hypothesis that beta1-adrenergic receptor blockade (beta1-RB) would attenuate LV remodeling after 4 mo of MR in the dog. beta1-RB did not attenuate collagen loss or the increase in LV mass in MR d...
متن کاملEvaluation of diastolic blood flow dynamic of the left ventricle in dogs with mitral valve regurgitation using vector flow mapping
Mitral valve regurgitation (MVR) is a common valvular disease in dogs. Hydrokinetic evaluation of the blood flow within the ventricles has become possible by vector flow mapping (VFM), which shows the blood flow within the ventricles in vector and vortex flows. Blood flow within the left ventricle of MVR dogs was compared at different stages of MVR and to that of normal dogs. 14 normal dogs and...
متن کاملAngiotensin II receptor blockade does not improve left ventricular function and remodeling in subacute mitral regurgitation in the dog.
OBJECTIVES We hypothesized that angiotensin II type-1 (AT(1)) receptor blocker (AT(1)RB) would prevent adverse left ventricular (LV) remodeling and LV dysfunction when started at the outset of mitral regurgitation (MR). BACKGROUND Little is known regarding the efficacy of AT(1)RB treatment of MR. METHODS Mitral regurgitation was induced by chordal disruption in adult mongrel dogs. Six norma...
متن کاملChymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure.
BACKGROUND Angiotensin (Ang) II, which plays a crucial role in the cardiac remodeling process, is generated via angiotensin-converting enzyme (ACE); however, an alternative generation pathway, chymase, which is stored in the mast cells, also exists in the heart. Cardiac chymase is insensitive to ACE inhibitors (ACEIs), and heart chymase promotes interstitial fibrosis by affecting collagen metab...
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